- Orexin pathway regulates appetite and energy
- Low Orexin causes excess appetite and sluggishness
- Orexin activating botanicals reduce appetite
- Increased energy
- Safe sources from food grade extracts (orange and jasmine flower)
Many people find it difficult to lose weight which is why some are resorting to injectable medications for the GLP-1 pathway, but often overlooked is low levels in the brain of the Orexin pathway. This also plays a major role in weight control apart from the important insulin-GLP-1 pathway as a weight loss mode of action mainly through reducing excessive appetite. It also works through increasing energy and physical activity to expend more calories, but reduces the need to eat afterwards.
Orexin is found in the hypothalamus of the brain region important for basic functions like appetite, sleep, body temperature, in other words it regulates a whole range of essential functions, and low levels of Orexin can cause hunger and fatigue. Much research has documented the role of orexin in obesity treatment resistance so this might be one the solutions we’ve been looking for. The orexin pathway promotes weight loss by increasing the urge for physical activity and promotes overall energy and at the same time improves glucose control to help reduce fat accumulation. Substances that activate the orexin neurons pathway have already shown benefits for reducing excess body fat.
Jamine flower contains the bioactive methyl jasmonate which at very low dosages in test animals of just 2.5 to 10 mcg decreased food intake through the Orexin pathway in the hypothalamus of the brain. The compound methyl jasmonate is what gives jasmine green tea its wonderful aromatic flavor with the addition of dried jasmine flowers or the aroma extract.
A flavonoid-rich extract of orange (Citrus sinensis) given to diet-induced obese test animals caused significant decreases in both body weight and BMI values and lowered the visceral adipose tissue. It also reduced adipocyte or fat cell size in both visceral and subcutaneous fat tissues. The orange extract modulated orexin genes and also other obesity-related genes such as leptin A, ghrelin in the gut and brain for a broad-spectrum comprehensive weight reducing effect. Orange extracts have a pleasant flavor and can be added to functional foods and beverages or directly used as a dietary supplement.
Draco can supply both custom Orange flavonoid extracts and Jasmine flower extracts rich in methyl jasmonate for creating a powerful weight loss and energy drink or supplement.
Cosmetic Corner: Jasmine Flower rich in oleuropein for reducing skin inflammatory stresses Oleuropein is a phenolic compound commonly found in both olive leaves and jasmine flowers with many skin benefits. Oleuropein’s anti-inflammatory and antioxidant activities were tested in human skin cells in a cell-based inflammasome model with human monocytes (THP-1 cells). Oleuropein reduced proinflammatory cytokine interleukin (IL)-6 by 38.8%-45.5%. Another benefit was that it alleviated oxidative stress in keratinocytes (HaCaT cells) by reducing hydrogen peroxide-induced cell death (Li,